The recurrence risk of genetic complex diseases
نویسندگان
چکیده
منابع مشابه
the recurrence risk of genetic complex diseases
complex inherited diseases affected by an interaction between collective effects of the genotype at one or multiple loci either to increase or to lower susceptibility to disease, combined with a variety of environmental exposures that may trigger, accelerate, exacerbate, or protect against the disease process. the new aspects of genetic techniques have been opened for diagnosis and analysis of ...
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The majority of important medical disorders (f.i. susceptibility to cancer, cardiovascular diseases, diabetes, Crohn’s disease) are said to be complex. This means that these diseases are influenced by multiple, often interacting environmental and genetic risk factors. The fact that individuals di↵er in terms of exposure to environmental as well as genetic factors explains the observed inter-ind...
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A statistic is introduced that relates discoveries made in genome-wide association (GWA) studies to patterns of disease risks among relatives. The genotype-specific recurrence risk (GSR) is the genotype-specific risk to relatives of known relationship to affected probands. The GSRs can be used for three purposes. (1) They can provide an independent test of whether an allele identified in a GWA ...
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*Please consult the online schedule for this course for the definitive date and time for this lecture. Key Concepts vs Supplementary Information: The syllabus is meant to accompany the lectures and the material covered (other) than that in italics) is considered important to your understanding of the subject. Key items are marked in bold. Supplemental information is marked in italics. Lecture O...
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A trait is often of interest by virtue of being either highly desirable, for example intelligence, or highly undesirable, for example cancer. Genetic influence over the trait can be established inmanyways including twin studies, clustering statistics and statistical modelling. Once the existence of a genetic component has been established, the next step is to locate the genes involved. The ease...
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ژورنال
عنوان ژورنال: Journal of Research in Medical Sciences
سال: 2017
ISSN: 1735-1995
DOI: 10.4103/1735-1995.202143